N1-Methylpseudouridine: Mechanistic Insight and Strategic...

2025-10-18

This thought-leadership article explores the transformative role of N1-Methylpseudouridine in mRNA therapeutics, providing a mechanistic deep dive, experimental rationale, and strategic guidance for translational researchers. By integrating evidence from recent cancer metastasis studies and highlighting best practices in mRNA modification, the article positions N1-Methylpseudouridine as an essential tool in overcoming immunogenicity and translation barriers, advancing applications in cancer, neurodegenerative, and metabolic disease models.